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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia
Beom Joon Kim1, Mi-Young Oh, Myung Suk Jang
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|April 24, 2012
Summary
Post-stroke memory problems may signal underlying Alzheimer's disease (AD). Amnestic vascular cognitive impairment after stroke, like mild cognitive impairment, shows more medial temporal atrophy, suggesting AD pathology.
Area of Science:
- Neurology
- Neuroscience
- Gerontology
Background:
- Post-stroke memory dysfunction prevalence may be underestimated.
- Stroke can co-occur with underlying Alzheimer's disease (AD).
Purpose of the Study:
- To determine if post-stroke memory dysfunction indicates subclinical Alzheimer's disease (AD).
Main Methods:
- Compared medial temporal atrophy (MTA) in patients with post-stroke amnestic (aVCIND) and nonamnestic (naVCIND) vascular cognitive impairment-no dementia, and non-stroke amnestic mild cognitive impairment (aMCI).
- Utilized neuropsychological testing and MRI at least 90 days post-stroke.
- Assessed MTA visually as a marker for AD pathology.
Main Results:
- Significantly lower MTA scores in the naVCIND group compared to aVCIND and aMCI groups.
- Increased odds of severe MTA associated with post-stroke aVCIND and non-stroke aMCI compared to naVCIND.
Conclusions:
- Post-stroke amnestic vascular cognitive impairment (aVCIND) and non-stroke amnestic mild cognitive impairment (aMCI) are associated with increased medial temporal atrophy (MTA) compared to nonamnestic vascular cognitive impairment (naVCIND).
- Findings suggest a potential link between certain post-stroke cognitive deficits and underlying Alzheimer's disease pathology.
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