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Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia

Beom Joon Kim1, Mi-Young Oh, Myung Suk Jang

  • 1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|April 24, 2012
PubMed
Abstract

Insights

Post-stroke memory problems may signal underlying Alzheimer's disease (AD). Amnestic vascular cognitive impairment after stroke, like mild cognitive impairment, shows more medial temporal atrophy, suggesting AD pathology.

Area of Science:

  • Neurology
  • Neuroscience
  • Gerontology

Background:

  • Post-stroke memory dysfunction prevalence may be underestimated.
  • Stroke can co-occur with underlying Alzheimer's disease (AD).

Purpose of the Study:

  • To determine if post-stroke memory dysfunction indicates subclinical Alzheimer's disease (AD).

Main Methods:

  • Compared medial temporal atrophy (MTA) in patients with post-stroke amnestic (aVCIND) and nonamnestic (naVCIND) vascular cognitive impairment-no dementia, and non-stroke amnestic mild cognitive impairment (aMCI).
  • Utilized neuropsychological testing and MRI at least 90 days post-stroke.
  • Assessed MTA visually as a marker for AD pathology.

Main Results:

  • Significantly lower MTA scores in the naVCIND group compared to aVCIND and aMCI groups.
  • Increased odds of severe MTA associated with post-stroke aVCIND and non-stroke aMCI compared to naVCIND.

Conclusions:

  • Post-stroke amnestic vascular cognitive impairment (aVCIND) and non-stroke amnestic mild cognitive impairment (aMCI) are associated with increased medial temporal atrophy (MTA) compared to nonamnestic vascular cognitive impairment (naVCIND).
  • Findings suggest a potential link between certain post-stroke cognitive deficits and underlying Alzheimer's disease pathology.
Keywords:
memory dysfunctionpoststroke dementiastrokevascular cognitive impairment

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