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Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
Jun Yup Kim1, Keon-Joo Lee1, Jihoon Kang1
1Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Journal of Korean Medical Science
|April 5, 2022
Summary
Elevated fasting and non-fasting triglycerides are common in acute ischemic stroke patients but do not predict future cardiovascular events or mortality within one year.
Area of Science:
- Cardiology
- Neurology
- Metabolic Disorders
Background:
- Elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) are common in acute ischemic stroke (AIS) patients.
- The clinical significance of these triglyceride levels in AIS is not well understood.
- Understanding these associations is crucial for risk stratification and management.
Purpose of the Study:
- To investigate the correlation between FTG and NFTG levels and their clinical significance in patients with AIS.
- To determine if triglyceride levels are associated with patient characteristics and clinical outcomes.
Main Methods:
- A multicenter prospective stroke registry was used to identify AIS patients.
- Patients hospitalized within 24 hours of onset with available NFTG results were included.
- The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year.
Main Results:
- The study included 2,176 AIS patients, with hypertriglyceridemia prevalence of 11.5% (fasting) and 24.6% (non-fasting).
- Younger age, diabetes, higher BMI, and higher systolic blood pressure were associated with both FTG and NFTG.
- Higher quartiles of NFTG and FTG were linked to specific demographic and clinical factors, but not to the composite outcome.
Conclusions:
- Fasting and non-fasting hypertriglyceridemia are prevalent in AIS patients and share similar clinical characteristics.
- Elevated FTG and NFTG levels were not associated with an increased risk of subsequent clinical events up to one year post-stroke.
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