Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Predictive Factors in OCT Analysis for Visual Outcome in Exudative AMD.

Maria-Andreea Gamulescu1, Georgios Panagakis, Carmen Theek

  • 1University Eye Clinic, Franz-Josef-Strauss Allee 11, 93051 Regensburg, Germany.

Journal of Ophthalmology
|April 24, 2012
PubMed
Summary

Outer retinal layer continuity on OCT scans did not predict visual acuity outcomes in patients with age-related macular degeneration (AMD) receiving ranibizumab injections. This finding suggests other factors may influence treatment success in AMD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nutrition and dietary supplements in age-related macular degeneration.

Die Ophthalmologie·2026
Same author

Neovascular Age-Related Macular Degeneration and GLP-1 RAs.

JAMA ophthalmology·2025
Same author

[Nutrition and dietary supplements in age-related macular degeneration].

Die Ophthalmologie·2025
Same author

[Artificial Intelligence in Retinology].

Klinische Monatsblatter fur Augenheilkunde·2025
Same author

Central retinal volume derived from optical coherence tomography as a potential predictor of mortality in the old-aged population- results from the German AugUR study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2025
Same author

[Smoking and eye diseases].

Die Ophthalmologie·2025

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Imaging

Background:

  • Predictive factors for therapy outcomes in exudative age-related macular degeneration (AMD) are crucial for patient counseling.
  • Intravitreal ranibizumab is a common treatment for AMD, but predicting individual responses remains challenging.

Purpose of the Study:

  • To investigate the predictive value of outer retinal layer integrity on optical coherence tomography (OCT) for visual acuity outcomes after intravitreal ranibizumab therapy in AMD patients.

Main Methods:

  • Retrospective analysis of 87 exudative AMD patients receiving three monthly intravitreal ranibizumab injections.
  • Preoperative OCT assessment of outer retinal layers: external limiting membrane (ELM), inner photoreceptor segments (IPS), IS/OS junction, and outer photoreceptor segments (OPS).

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Related Experiment Videos

Last Updated: May 23, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

  • Comparison of visual acuity before treatment and 4-6 weeks after the last injection.

    • Main Results:

    • Visual acuity improved in 46.0%, remained stable in 28.7%, and decreased in 25.3% of patients post-treatment.
    • No statistically significant correlation was found between the grade of outer retinal layer continuity and visual acuity development.

    Conclusions:

    • The continuity of outer retinal layers, as visualized by OCT, was not a significant predictor of visual acuity outcomes in this cohort of AMD patients treated with ranibizumab.
    • Further research is needed to identify reliable predictive factors for ranibizumab therapy response in age-related macular degeneration.