[Some aspects of prostaglandin administration in obstetrics: preliminary report]

Prostaglandin preparations are widely used in the OB-GYN practice today. This is due to their high efficiency and their potency to prevent a surgical intervention and serious complications. The aim of this study is to share our experience in the prevention of hypo- and atonic, itra- and postoperative hemorrhage after Caesarian Section on multiple pregnancy.

31 patients with multiple pregnancy for the period of Jan 2010 to June 2011, delivered by Cesarean Section due to unfavorable fetus presentation. Time of delivery- 34 to 38 weeks of gestation. 13 of them represented our work group, amongst them 11 with twin pregnancy and 2 with triplets. They were administered, in theatre, prostaglandin F2alpha as 1 ampule of Prostin 15M (Carboprost tromethamole 0.25 mg) in the uterus wall, as a prophylaxis. The control group consisted of 18 multiple pregnancy patients, chosen randomly and delivered again by C.S., 14 of them with twin pregnancy and 4 with triplets.

In our work group the average maternal blood loss was 520 ml +/- 104 ml, compared to 760 +/- 80 ml in the control group. There were patients in the control group with average blood loss of 1500 ml leading to the need of urgent and lifesaving measures.

Nevertheless the small number of cases we had, we dare to say the administration of Carboprost tromethamole - Prostin 15M, intramurally in the uterus during Cesarean section on multiple pregnancy, diminishes the risk of severe hypo- and atonic hemorrhage in theatre and postpartum.