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Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema01:23

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Related Experiment Video

Updated: May 23, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

Spontaneous subcutaneous emphysema associated with mephedrone usage.

Z N Maan1, A R D'Souza

  • 1Department of Otolaryngology-Head and Neck Surgery, Colchester Hospital University NHS Foundation Trust, Essex, UK. zeshaan@doctors.org.uk

Annals of the Royal College of Surgeons of England
|April 25, 2012
PubMed
Summary

Spontaneous cervical subcutaneous emphysema, a rare condition, occurred in a man after snorting mephedrone. This non-traumatic case highlights a previously undescribed association, with the patient recovering without airway support.

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Last Updated: May 23, 2026

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Area of Science:

  • Medical Case Reports
  • Toxicology
  • Otolaryngology

Background:

  • Subcutaneous emphysema in the head and neck is typically associated with significant trauma to the airway or gastrointestinal tract.
  • It is a rare clinical presentation, often requiring extensive medical intervention.

Observation:

  • A 30-year-old male presented with spontaneous cervical subcutaneous emphysema.
  • The patient reported a history of recreational mephedrone use via nasal insufflation (snorting).
  • No direct trauma to the head, neck, or airway was identified.

Findings:

  • The case represents the first reported instance of spontaneous cervical subcutaneous emphysema linked to mephedrone use.
  • Conservative management was successful, and the patient did not require respiratory support.
  • Diagnostic workup ruled out other common causes of emphysema.

Implications:

  • This case suggests a potential, previously unrecognized complication of mephedrone abuse.
  • Clinicians should consider recreational drug use, particularly mephedrone, in the differential diagnosis of non-traumatic cervical emphysema.
  • Further research is warranted to understand the mechanism linking mephedrone to spontaneous emphysema.