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Vitamin D in kidney disease: pathophysiology and the utility of treatment
Rizwan A Qazi1, Kevin J Martin
1Division of Nephrology, Saint Louis University, Saint Louis, MO 63110, USA. qazir@SLU.EDU
Abstract:
CKD is associated with decreased vitamin D metabolites, both the storage form 25(OH)D and the active form 1,25-dihydroxyvitamin D. This contributes to hyperparathyroidism, and increased levels of PTH mobilize minerals from the skeleton and increase the risk for fractures. Treatment with vitamin D sterols efficiently reduces secondary hyperparathyroidism of CKD. Observational studies suggest survival and other potential benefits of vitamin D treatment in the CKD population. These observations need to be verified with controlled prospective trials.
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