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Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis.

Katja Scheffler1, Markus Krohn, Tina Dunkelmann

  • 1Department of Neurology, Neurodegeneration Research Laboratory (NRL), Universities of Rostock, Rostock, Germany.

Acta Neuropathologica
|April 25, 2012
PubMed
Summary

Mitochondrial DNA (mtDNA) variations impact brain energy metabolism and microglial function, influencing Alzheimer's disease (AD) pathology. Enhanced mitochondrial function in microglia reduces amyloid-beta accumulation, suggesting a key role for mitochondrial health in neuroprotection.

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