Related Experiment Video
Updated: May 22, 2026

14:11
Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines
1Department of Biochemistry and Molecular Biology, and Indiana University Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Organic & Biomolecular Chemistry
|April 25, 2012
Abstract:
A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids. To demonstrate the versatility of our method, a representative library of 108 tetrasubstituted pyrrolo[2,3-d]pyrimidines of high quality was synthesized.

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)