Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Location of visual field defects and their impact on vision-related quality of life in glaucoma: A systematic review.

Optometry and vision science : official publication of the American Academy of Optometry·2026
Same author

Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Glaucomatous Remodeling of the Lamina Cribrosa: Association With Visual Field Progression.

Investigative ophthalmology & visual science·2026
Same author

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Forecasting mean deviation in glaucoma patients using an irregular autoregressive time series method.

Scientific reports·2025
Same author

Automated Spectral-Domain Versus Swept-Source OCT Angiography in Relation to Glaucoma Severity.

Journal of glaucoma·2025

Related Experiment Video

Updated: May 22, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

The effect of test variability on the structure-function relationship in early glaucoma.

Stuart K Gardiner1, Chris A Johnson, Shaban Demirel

  • 1Discoveries In Sight Laboratories, Devers Eye Institute, Legacy Health System, 1225 NE 2nd Ave, Portland, OR 97232, USA. sgardiner@deverseye.org

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|April 25, 2012
PubMed
Summary

Test variability in glaucoma assessments is substantial, potentially explaining apparent structure-function disconnects without true biological dissociation. This finding supports combining structural and functional measures for improved glaucoma progression estimates.

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Related Experiment Videos

Last Updated: May 22, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Vision Science

Background:

  • The relationship between structural damage and functional vision loss in glaucoma is complex.
  • Understanding test variability is crucial for accurate glaucoma progression assessment.
  • Previous studies have suggested a weak structure-function relationship in glaucoma.

Purpose of the Study:

  • To investigate whether test variability alone can account for the observed weakness in the structure-function relationship in glaucoma.
  • To determine if apparent dissociation between structural and functional changes is solely due to measurement error.

Main Methods:

  • Utilized data from the Portland Progression Project, including perimetric mean deviation (MD), rim area (RA), and cup volume (CV) from 166 eyes.
  • Developed models to simulate functional and structural data sequences, varying the standard deviation (σ) of underlying change rates.
  • Calculated 'observed' structure-function relationships and empirical p-values from simulated data to compare with patient data.

Main Results:

  • The correlation between rates of structural (RA) and functional (MD) change was 0.171 (σ < 0.02 dB/yr).
  • Using cup volume (CV), the correlation was -0.091 (σ < 0.01 dB/yr).
  • Models predicted test variability alone could result in a standard deviation of 0.18 dB/yr for functional change rate in healthy eyes.

Conclusions:

  • Substantial test variability in glaucoma assessments can simulate weak structure-function relationships.
  • This suggests that apparent dissociation may not require underlying biological differences in change rates.
  • The findings support the validity of combining structural and functional measures to enhance glaucoma progression estimates and reduce measurement variability.