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A hydrogel pericardial patch.

M A Allder1, E J Guilbeau, T A Brandon

  • 1Department of Chemical, Bio, and Materials Engineering, Arizona State University, Tempe 85287-6006.

ASAIO Transactions
|July 1, 1990
PubMed
Summary
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A new composite patch made of hydrogel and ethylene tetrafluoroethylene (ETFE) mesh can augment pericardial tissue. The 45-degree oriented patch closely matches native pericardium properties, showing promise for repeat cardiac surgery patients.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Tissue Engineering

Background:

  • Repeat cardiac operations pose higher risks due to potential adhesion formation from incomplete pericardial closure.
  • Augmentation of pericardial tissue is crucial when primary closure is not feasible.

Purpose of the Study:

  • To develop and evaluate a novel composite patch for augmenting pericardial tissue.
  • To assess the mechanical properties of the composite patch compared to native pericardium.

Main Methods:

  • Fabrication of a composite patch using poly (2-hydroxyethyl methacrylate) hydrogel reinforced with an ethylene tetrafluoroethylene (ETFE) mesh.
  • Two patch orientations were created: perpendicular and 45 degrees to the loading direction.
  • Mechanical testing, including ultimate tensile strength and suture strength, was performed and compared to canine pericardium.

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Main Results:

  • The composite patches exhibited ultimate tensile strength comparable to canine pericardium.
  • Suture strength of the patches was approximately double that of canine pericardium.
  • The 45-degree oriented patch demonstrated mechanical properties similar to native canine pericardium, unlike the stiffer perpendicular patch.

Conclusions:

  • The developed composite patch, particularly the 45-degree variant, shows significant potential as a pericardial substitute.
  • This biomaterial could improve outcomes for patients undergoing repeat cardiac surgeries by mitigating risks associated with pericardial defects.