Related Experiment Videos
Venturi grafts for hemodialysis access.
W J Drasler1, G J Wilson, M L Jenson
1Possis Medical, Inc. Minneapolis, Minnesota 55427.
ASAIO Transactions
|July 1, 1990
Summary
This study introduces a novel vascular access graft with venturi flow resistance, significantly reducing venous pressure and improving puncture site healing in a canine model. The graft demonstrates potential for enhanced patient outcomes in hemodialysis.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
Background:
- Vascular access grafts are prone to stenosis and excessive shunted flow.
- Current grafts may lead to complications like venous stenosis and puncture site issues.
Purpose of the Study:
- To evaluate a novel vascular access graft with integrated venturi flow resistance.
- To assess the graft's ability to control shunted flow and reduce venous pressure.
- To compare healing and patency rates against standard grafts.
Main Methods:
- Implantation of twelve 6 mm ePTFE venturi grafts in a canine femoral arterio-venous (A-V) model.
- Simulated dialysis for up to 6 months with pressure, bleeding, and healing assessments.
- Comparison with nine control ePTFE grafts.
Main Results:
- Venturi grafts demonstrated similar patency rates (90%) to controls (89%) at 4 months.
- Venturi resistance dissipated pressure from 85 to 15 mmHg, delivering near-normal pressures to the vein.
- Improved puncture site healing, reduced bleeding times, and less mural thrombus observed upstream of the venturi.
Conclusions:
- The venturi vascular access graft effectively reduces venous pressure and improves puncture site healing.
- This design shows promise for reducing complications associated with hemodialysis vascular access.
- Potential clinical advantages include enhanced vein preservation and reduced bleeding complications.