Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Graphene nanopore devices for DNA sensing.

Chris A Merchant1, Marija Drndić

  • 1Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 25, 2012
PubMed
Summary

We developed a new method using graphene nanopores to detect DNA translocation. This technique offers improved signal detection and noise reduction for advanced molecular sensing applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the Continuum Theory: Conductance Scaling and Correlated Imaging in Atom-Scale Artificial Ion Channels.

ACS nano·2026
Same author

Nanopore event detection in a simple and adaptive way.

bioRxiv : the preprint server for biology·2026
Same author

Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions.

Beilstein journal of nanotechnology·2026
Same author

Uncovering Hidden Protein Conformations with High Bandwidth Nanopore Measurements.

Nano letters·2026
Same author

Uncovering hidden protein conformations with high bandwidth nanopore measurements.

ArXiv·2025
Same author

Geometrically Confined Strain Engineering of MoS<sub>2</sub> via Quasi-Van Der Waals Recrystallization of Gold Nanopillars.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Nanopore technology is crucial for single-molecule analysis.
  • Traditional solid-state nanopores face limitations in signal-to-noise ratio and conductivity.
  • Graphene's unique electrical properties offer potential for enhanced nanopore devices.

Purpose of the Study:

  • To present a novel method for detecting DNA molecule translocation through graphene nanopores.
  • To characterize the performance of these graphene-based nanopore devices.
  • To explore the advantages of graphene over traditional materials for nanopore sensing.

Main Methods:

  • Fabrication of thin graphene membranes with precisely sculpted nanopores (5-10 nm diameter).
  • Utilizing electron-beam sculpting for nanopore creation.
  • Applying atomic-layer deposition of titanium dioxide to reduce ionic current noise.

Main Results:

  • Observed significantly larger blocked currents compared to traditional solid-state nanopores due to graphene's thinness and low resistance.
  • Demonstrated effective reduction of ionic current noise by coating graphene with titanium dioxide.
  • Confirmed graphene's electrical conductivity enables direct electronic sensing and control at the pore.

Conclusions:

  • Graphene nanopores represent a promising platform for high-sensitivity DNA translocation detection.
  • The developed method enhances signal detection and noise reduction, overcoming limitations of conventional nanopores.
  • Graphene's conductivity paves the way for integrated electronic functionalities in future nanopore devices.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Related Experiment Videos

Last Updated: May 22, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022