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Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: May 22, 2026

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Heterogenecity of fibroblasts.

Manyam Ravikanth1, P Soujanya, K Manjunath

  • 1Department of Oral Pathology, Vishnu Dental College and Hospital, Bhimavaram, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|April 25, 2012
PubMed
Summary
This summary is machine-generated.

Fibroblasts, crucial for connective tissue, show significant variations in form and function. This heterogeneity reflects distinct cellular subsets important in both health and disease.

Keywords:
Fibroblastsfibrocytesgiant cell fibroblastsmyofibroblasts

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Related Experiment Videos

Last Updated: May 22, 2026

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Murine Dermal Fibroblast Isolation by FACS
06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

Ultrasonic-augmented Primary Adult Fibroblast Isolation
06:51

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

Area of Science:

  • Cell Biology
  • Connective Tissue Research
  • Histology

Background:

  • Fibroblasts are essential stromal cells in human connective tissue.
  • They play a vital role in maintaining structural integrity in healthy tissues.

Purpose of the Study:

  • To inform about the heterogeneity of fibroblasts.
  • To discuss fibroblast variability in physiological and pathological conditions.

Main Methods:

  • Literature review on fibroblast heterogeneity.
  • Analysis of morphological and functional variations.

Main Results:

  • Fibroblasts display considerable variation in morphology, size, and shape.
  • These variations suggest the existence of distinct fibroblast subsets.

Conclusions:

  • Fibroblast heterogeneity is a key feature in connective tissue.
  • Understanding this variability is crucial for comprehending physiological and pathological processes.