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Updated: May 22, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Syndecan-4 and fibronectin in osteosarcoma
Ki Yong Na1, Patrizia Bacchini, Franco Bertoni
1Department of Pathology, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.
Pathology
|April 26, 2012
Summary
Increased expression of syndecan-4 (SDC4) and fibronectin (FN) in osteosarcoma correlates with aggressive tumor behavior and poorer survival. These cell adhesion molecules may drive more invasive clinical characteristics.
Area of Science:
- Oncology
- Molecular Biology
- Biopathology
Background:
- Syndecan-4 (SDC4) and fibronectin (FN) are cell adhesion molecules implicated in tumor progression.
- Their prognostic significance in osteosarcoma remains to be fully elucidated.
Purpose of the Study:
- To investigate the prognostic value of SDC4 and FN expression in osteosarcoma.
- To compare SDC4 and FN expression across different grades of osteosarcoma and normal bone tissue.
Main Methods:
- Immunohistochemistry was employed to assess SDC4 and FN expression.
- Expression levels were analyzed in high-grade osteosarcoma, low-grade central osteosarcoma, osteoid osteoma, and normal bone.
- Correlation with prognostic factors in high-grade osteosarcoma was examined.
Main Results:
- SDC4 and FN expression were significantly increased in high-grade osteosarcoma compared to other tissues.
- Strong SDC4 expression correlated with distant metastasis and larger tumor size.
- Strong FN expression was associated with distant metastasis.
- Both strong SDC4 and FN expression were linked to significantly shorter overall survival.
Conclusions:
- Elevated SDC4 and FN expression are potential molecular drivers of aggressive osteosarcoma.
- These findings suggest SDC4 and FN as biomarkers for predicting clinical behavior in osteosarcoma.
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