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Green tea and lung cancer: a systematic review
Heidi Fritz1, Dugald Seely, Deborah A Kennedy
1Canadian College of Naturopathic Medicine, Toronto, ON, Canada.
Background:
Green tea is a beverage widely used by lung cancer patients and the public for its purported anticancer properties. The authors conducted a systematic review of green tea for the treatment and prevention of lung cancer.
Methodology:
Six electronic databases were searched from inception until November 2011 for human interventional and preclinical evidence pertaining to the safety and efficacy of green tea for lung cancer.
Results:
A total of 84 articles met inclusion criteria: two Phase I trials, three reports of one surrogate study, and 79 preclinical studies. There is a lack of controlled trials investigating green tea for lung cancer. Two Phase I studies showed no objective tumor responses at the maximum tolerated dose, ranging from 3 to 4.2 g/m(2) green tea extract (GTE) per day. Four cups of green tea daily decreased DNA damage (8OH-dG) in smokers. Human studies indicate that 800mg of green tea catechins daily does not alter activity of the CYP2D6, CYP1A2, CYP3A4 and CYP2C9 enzymes, however in vitro evidence suggests that green tea may bind to and reduce the effectiveness of bortezomib. Green tea applied topically may improve the healing time of radiation burns.
Conclusions:
Although some evidence suggests that chemopreventative benefits can be accrued from green tea, there is currently insufficient evidence to support green tea as a treatment or preventative agent for lung cancer. Green tea should not be used by patients on bortezomib therapy. Further research is warranted to explore this natural agent for lung cancer treatment and prevention.
Insights
While green tea may offer some cancer prevention benefits, current evidence is insufficient for its use in treating or preventing lung cancer. Patients on bortezomib therapy should avoid green tea due to potential interactions.
Area of Science:
- Oncology
- Pharmacology
- Nutritional Science
Background:
- Green tea is widely consumed for its potential anticancer properties.
- Lung cancer patients and the general public use green tea.
- This study systematically reviews green tea's role in lung cancer.
Purpose of the Study:
- To evaluate the efficacy and safety of green tea for lung cancer treatment and prevention.
- To synthesize evidence from human and preclinical studies.
- To identify potential interactions and adverse effects.
Main Methods:
- Systematic review of six electronic databases.
- Inclusion of human interventional and preclinical studies up to November 2011.
- Analysis of safety and efficacy data.
Main Results:
- 84 articles were included: 2 Phase I trials, 1 surrogate study, and 79 preclinical studies.
- No objective tumor responses were observed in Phase I trials at maximum tolerated doses of green tea extract (GTE).
- Daily consumption of four cups of green tea reduced DNA damage (8OH-dG) in smokers; 800mg of green tea catechins did not affect key drug-metabolizing enzymes (CYP450 family).
- Topical green tea may aid radiation burn healing, but in vitro data suggest interactions with bortezomib.
Conclusions:
- Insufficient evidence supports green tea as a lung cancer treatment or preventative agent.
- Green tea should not be used concurrently with bortezomib therapy.
- Further research is needed to explore green tea's potential in lung cancer management.
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