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Related Experiment Videos

Polyol concentrations in serum during hemodialysis.

J Roboz1, D Kappatos, J F Holland

  • 1Department of Neoplastic Diseases, Mount Sinai School of Medicine, New York, NY 10029.

Clinical Chemistry
|December 1, 1990
PubMed
Summary

Patients undergoing dialysis often have high levels of certain polyols, including erythritol and threitol, which remain elevated even after treatment. This suggests differences in how the body regulates and removes these sugar alcohols.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Metabolic Research

Background:

  • Polyols are sugar alcohols with various physiological roles.
  • Altered polyol metabolism is observed in certain disease states.
  • Dialysis is a treatment for kidney failure, impacting fluid and solute balance.

Purpose of the Study:

  • To quantify polyol concentrations in patients before and during dialysis.
  • To investigate the dialyzability and homeostatic differences among various polyols.
  • To assess residual polyol levels post-dialysis.

Main Methods:

  • Selected-ion monitoring was used to determine polyol concentrations.
  • Samples were collected from 10 patients before and hourly for 4 hours during dialysis.
  • Concentrations were compared to established upper limits of normal.

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Main Results:

  • Predialysis levels of erythritol, threitol, and arabinitol exceeded normal limits in all patients.
  • Mannitol and xylitol also showed elevated predialysis concentrations in most cases.
  • Polyol concentrations decreased by approximately 50% during dialysis, with exceptions for xylitol and adonitol.
  • Erythritol, threitol, and arabinitol remained significantly elevated post-dialysis.
  • High residual concentrations of mannitol and xylitol were noted.

Conclusions:

  • Significant differences exist in the homeostasis and dialyzability of various polyols.
  • Elevated residual polyol concentrations after dialysis warrant further investigation for potential toxicity.
  • Polyol metabolism and clearance require careful consideration in patients undergoing dialysis.