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Relationship between delta checks for selected chemistry tests.

D A Lacher1

  • 1Department of Pathology, Medical College of Ohio, Toledo 43699.

Clinical Chemistry
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Analyzing 20 serum chemistry tests revealed significant correlations between delta differences in patient samples. This quality control method can identify analytical errors, with aspartate aminotransferase and alanine aminotransferase showing the strongest link.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Biochemistry

Background:

  • Delta checks are crucial for monitoring laboratory test results over time.
  • Identifying correlations between different tests can enhance quality control protocols.
  • Understanding these relationships aids in detecting analytical interferences or errors.

Purpose of the Study:

  • To investigate the correlations between delta differences of multiple serum chemistry tests.
  • To evaluate the potential of using these correlations as a quality-control measure.
  • To identify specific test pairs with significant delta check correlations.

Main Methods:

  • Calculated correlation coefficients for delta differences across 20 serum chemistry tests.
  • Analyzed data from 2400 samples obtained from 288 patients.

Related Experiment Videos

  • Identified pairs of tests with correlation coefficients exceeding a threshold of 0.25.

    • Main Results:

    • Twelve pairs of chemistry tests exhibited delta check correlation coefficients greater than 0.25.
    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) showed the highest positive correlation (0.915).
    • Bicarbonate and chloride delta checks displayed the strongest negative correlation (-0.219).

    Conclusions:

    • The relationship between delta differences in serum chemistry tests is a viable quality-control technique.
    • Correlations can effectively detect analytical errors in laboratory testing.
    • Specific test pairs, like AST/ALT and bicarbonate/chloride, provide valuable insights into analytical performance.