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A new lignan with anti-tumour activity from Polygonum perfoliatum L
Kui-Wu Wang1, Jun-Ru Zhu, Lian-Qing Shen
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, PR China. wkw220@yahoo.com.cn
Abstract:
The methanol extract of the tubers of Polygonum perfoliatum L. afforded a new lignan: 8-oxo-pinoresinol (1), and five known compounds 3',5-dihydroxy-3,4',5',7-tetramethoxy-flavone (2), catechin (3), quercetin (4), quercetin-3-O-β-D-glucuronide (5) and rutin (6). Their structures were established by MS, one- and two-dimensional NMR experiments. Compound 1 showed cytotoxicity against human mammary carcinoma (Bcap-37), human colon carcinoma (RKO), human hepatocellular carcinoma (SMMC-7721), human prostate carcinoma (PC3) and human erythroleukaemia (K562) cells.
