[Clinicopathological features and immunohistological diagnosis of olfactory neuroblastoma]

Nasal olfactory neuroblastoma and other malignant neoplasms showing spherical cell are easily confused in clinical and pathological diagnosis. We have made immunohistochemical staining in 7 olfactory neuroblastoma cases. Results showed that they were all positively stained by NSE, and negatively by keratin, leucocyte common antigen, desmin and S-100 protein (except 1 positive by desmin). We believe that the olfactory neuroblastoma cells are uniform morphologically. The cells are round, elliptic, having scant cytoplasm; with coarse or fine chromatin. Neurofibers can be found among tumor cells. Their histological structures vary greatly. They may form nest or garland, and they may also form striation, cleft or discrete structure; but rosette or pseudo-rosette structure is uncommon.