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Wilms' Tumor with long-delayed recurrence: 25 years after initial treatment
So-Young Lee1, Kyu-Rae Kim, Jung-Yeol Park
1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. soyounglee99@gmail.com
Korean Journal of Urology
|April 27, 2012
Summary
This case report details a rare late recurrence of Wilms tumor (a childhood kidney cancer) 25 years after initial treatment. This represents the longest disease-free interval ever documented for Wilms tumor relapse.
Area of Science:
- Pediatric Oncology
- Nephrology
- Cancer Recurrence
Background:
- Wilms tumor is a common pediatric malignancy.
- Treatment advances have improved survival rates.
- Late recurrence of Wilms tumor remains a clinical challenge.
Purpose of the Study:
- To report an extraordinary case of long-delayed Wilms tumor recurrence.
- To discuss potential mechanisms for late relapse after extensive treatment.
Main Methods:
- Case presentation of a 28-year-old female with a pelvic mass.
- Review of patient's history including radical nephrectomy and chemotherapy at age three.
- Histopathological confirmation of recurrent Wilms tumor.
Main Results:
- A pelvic mass was diagnosed as recurrent Wilms tumor 25 years after initial treatment.
- The recurrent tumor exhibited classic triphasic histology with high mitotic activity and necrosis.
- This represents the longest reported disease-free interval for Wilms tumor.
Conclusions:
- Late relapses of Wilms tumor, though rare, can occur decades after initial therapy.
- Chemotherapy's long-term effects and other biological factors may contribute to late recurrences.
- This case highlights the importance of long-term surveillance for Wilms tumor survivors.
