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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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Platelet-rich fibrin matrix for facial plastic surgery

Anthony P Sclafani1, Masoud Saman

  • 1Division of Facial Plastic and Reconstructive Surgery, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA. asclafani@nyee.edu

Facial Plastic Surgery Clinics of North America
|April 28, 2012
PubMed

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.