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Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Mid-aortic syndrome in two preterm infants.

A Izraelit1, M Kim, V Ratner

  • 1Division of Neonatology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|April 28, 2012
PubMed
Summary

Mid-aortic syndrome (MAC) is a rare condition causing severe hypertension in infants. This report details two premature infants with MAC who unfortunately died early due to treatment-resistant hypertension.

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Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Vascular Biology

Background:

  • Mid-aortic syndrome (MAC) is a rare congenital anomaly characterized by narrowing of the mid-thoracic or abdominal aorta.
  • It often presents with severe, difficult-to-manage hypertension, particularly in neonates and infants.
  • Early diagnosis and intervention are crucial for improving outcomes, though challenges remain.

Observation:

  • This report describes two preterm infants diagnosed with mid-aortic syndrome (MAC).
  • Both infants presented with malignant hypertension that was refractory to all medical management.
  • These cases represent the youngest patients with MAC reported to date.

Findings:

  • The two preterm infants with mid-aortic syndrome (MAC) experienced severe, uncontrolled hypertension.
  • Despite aggressive medical therapy, both infants succumbed to the condition early in infancy.
  • This highlights the critical and often fatal nature of MAC in extremely premature neonates.

Implications:

  • The findings underscore the severe prognosis of mid-aortic syndrome (MAC) in very young, preterm infants.
  • There is an urgent need for improved diagnostic and therapeutic strategies for MAC in neonates.
  • Further research into the pathophysiology and management of MAC is essential to improve survival rates.