[Use of monoclonal antibodies in clinical oncology]

Clinical possibilities of using monoclonal antibodies (MCA) in the immunodiagnosis of malignant neoplasms have been analysed. Certain Soviet and foreign MCA to tumor-associated antigens have been characterized, and their clinical importance has been estimated. A special attention has been paid to MCA against "cross", i.e. leukemia-associated, antigens. Basing on the data obtained it has been established that the use of even two MCA series (ICO-10 and ICO-20) makes available sufficiently accurate information on the tumor histogenesis. Besides that, MCA ICO-63, HNK-1, ICO-10, ICO-46 can be used for immunophenotyping of some solid tumors, particularly, for the immunophenotyping of human neuroblastoma cells.