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The relationship between lung inflammation and cardiovascular disease
Stephan Van Eeden1, Jonathon Leipsic, S F Paul Man
1Division of Respiratory Medicine, Department of Medicine, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada.
American Journal of Respiratory and Critical Care Medicine
|April 28, 2012
Summary
Lung inflammation from factors like smoke and pollution is a key risk for heart disease. Research links airway inflammation to acute cardiovascular events, highlighting a causal relationship.
Area of Science:
- Cardiology
- Pulmonology
- Environmental Health
Background:
- Lung inflammation is an emerging risk factor for cardiovascular disease (CVD).
- Epidemiological data link airway exposures (cigarette smoke, air pollution, pathogens) to acute ischemic events.
- Recent human and animal studies provide experimental evidence for a causal relationship.
Purpose of the Study:
- To review epidemiological data on the lung inflammation-cardiovascular disease link.
- To explore mechanistic pathways connecting lung inflammation to cardiovascular syndromes.
Main Methods:
- Review of epidemiological studies.
- Analysis of human and animal experimental data.
- Examination of proposed mechanistic pathways.
Main Results:
- Strong epidemiological association between airway exposures and acute ischemic events.
- Experimental evidence supports a causal link between lung inflammation and CVD.
- Plausible mechanistic pathways identified.
Conclusions:
- Acute and chronic lung inflammation are significant, underrecognized risk factors for cardiovascular disease.
- Understanding these links is crucial for preventing cardiovascular events.
- Further research into mechanistic pathways can inform therapeutic strategies.
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