[Necessity of defunctioning stoma in low anterior resection for rectal cancer: a meta-analysis]
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Updated: May 22, 2026
The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
Published on: November 4, 2010
Yi Sun1, Hong-jie Yang, Yong-gang Lu
1Department of General Surgery, Southern Medical University, Guangxi Liuzhou, China. sunyi1166@sina.com
Objective:
To evaluate the necessity of defunctioning stoma in low anterior resection for rectal cancer below peritoneal reflection.
Methods:
The databases of Medline, Embase, Cochrane Library, Wanfang and CNKI were searched. The eligible studies were identified for pooled analyses.
Results:
Six randomized controlled trials with 648 cases(332 patients with defunctioning stoma and 316 without stoma) and 25 retrospective controlled trials with 10,722 cases(4,470 patients with defunctioning stoma and 6,252 without stoma) were included. Combined analyses showed that defunctioning stoma was effective for decreasing risk of postoperative anastomotic leakage (RR=0.33 and 95% CI:0.21-0.53 for RCTs, OR=0.60 and 95% CI:0.42-0.85 for retrospective studies), reoperation (RR=0.30, 95% CI:0.16-0.53 for RCTs, OR=0.26 and 95% CI:0.21-0.32 for retrospective studies) and mortality(OR=0.41, 95% CI:0.27-0.62 for retrospective studies).
Conclusion:
Defunctioning stoma should be routinely performed in low anterior resection for high-risk patients.
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