Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mnemonic Devices01:23

Mnemonic Devices

Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
Forgetting01:21

Forgetting

Forgetting is an intrinsic aspect of human memory, characterized by the gradual loss or inaccessibility of information over time. Hermann Ebbinghaus, a pioneering psychologist, extensively studied this phenomenon and formulated the forgetting curve. This curve illustrates that memory loss occurs rapidly immediately after learning and then decelerates over time. Several mechanisms contribute to forgetting, including encoding failure, storage decay, retrieval failure, and interference.
Encoding...
Understanding Memory01:19

Understanding Memory

Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
System of Memory01:23

System of Memory

Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
Long-Term Memory01:18

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Implicit Memories01:24

Implicit Memories

Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic Inheritance Through Replication-Coupled Parental Histone Recycling.

Annual review of cell and developmental biology·2026
Same author

Requirements for establishment and epigenetic stability of mammalian heterochromatin.

Molecular cell·2025
Same author

Catalytic pocket of Clr4 (Suv39h) methyltransferase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination.

bioRxiv : the preprint server for biology·2025
Same author

A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Cell·2024
Same author

Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing.

Science advances·2024
Same author

Minimal requirements for the epigenetic inheritance of engineered silent chromatin domains.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

A Real-world What-Where-When Memory Test
09:13

A Real-world What-Where-When Memory Test

Published on: May 16, 2017

A piRNA to remember.

Danesh Moazed1

  • 1Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. danesh@hms.harvard.edu

Cell
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Small RNAs called piRNAs, typically found in the germline, surprisingly regulate genes in the sea slug

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Related Experiment Videos

Last Updated: May 22, 2026

A Real-world What-Where-When Memory Test
09:13

A Real-world What-Where-When Memory Test

Published on: May 16, 2017

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Small RNAs, particularly PIWI-interacting RNAs (piRNAs), were primarily known for their role in silencing transposable elements in the germline.
  • The central nervous system's role in complex cognitive functions like memory formation is well-established.
  • The sea slug Aplysia californica is a model organism for studying the molecular basis of learning and memory.

Discussion:

  • This study reveals a novel function for piRNAs beyond germline transposon control.
  • The research demonstrates piRNA involvement in regulating plasticity-related genes within the central nervous system.
  • These findings challenge the established understanding of piRNA biology and neuronal function.

Key Insights:

  • PIWI-interacting RNAs (piRNAs) are implicated in transcriptional regulation of neural plasticity genes.
  • This discovery expands the known functional repertoire of small RNAs in the nervous system.
  • The study links piRNA activity to the molecular mechanisms underlying memory.

Outlook:

  • Further investigation into piRNA-mediated gene regulation in other species and neuronal contexts is warranted.
  • Understanding this new role of piRNAs could offer novel therapeutic targets for memory disorders.
  • This work opens new avenues for exploring the complex interplay between small RNAs and cognitive processes.