Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

6.1K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
6.1K
Chromosome Replication02:31

Chromosome Replication

8.8K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
8.8K
Histone Modification02:32

Histone Modification

14.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.3K
Histone Modification02:32

Histone Modification

4.0K
4.0K
Replication in Eukaryotes01:29

Replication in Eukaryotes

15.0K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical artificial intelligence applications of vision-language foundation models.

PLOS digital health·2026
Same author

Requirements for establishment and epigenetic stability of mammalian heterochromatin.

Molecular cell·2025
Same author

Beaver behavior optimizer: A novel metaheuristic algorithm for solar PV parameter identification and engineering problems.

Journal of advanced research·2025
Same author

Catalytic pocket of Clr4 (Suv39h) methyltransferase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination.

bioRxiv : the preprint server for biology·2025
Same author

Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study.

Schizophrenia research. Cognition·2025
Same author

Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model.

Scientific reports·2025
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
08:53

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

1.1K

Epigenetic Inheritance Through Replication-Coupled Parental Histone Recycling.

Juntao Yu1,2, Danesh Moazed1

  • 11Department of Cell Biology, Howard Hughes Medical Institute, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA;

Annual Review of Cell and Developmental Biology
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Parental histone recycling during DNA replication ensures the faithful inheritance of silent chromatin. This epigenetic mechanism maintains gene silencing across cell divisions.

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.3K

Related Experiment Videos

Last Updated: Apr 22, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
08:53

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

1.1K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.3K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Chromatin Biology

Background:

  • Epigenetic inheritance of repressed chromatin domains is crucial for stable gene silencing in eukaryotes.
  • Silent chromatin relies on repressive histone modifications and a read-write mechanism for propagation.
  • Parental histone recycling during DNA replication is vital for maintaining chromatin states.

Purpose of the Study:

  • To elucidate the role of DNA replication machinery and histone chaperones in parental histone transfer.
  • To provide evidence for the necessity of symmetrical parental histone transfer in epigenetic inheritance of silent chromatin.

Main Methods:

  • Investigated the mechanisms of parental histone transfer during DNA replication.
  • Examined the function of histone chaperones associated with the DNA replication machinery.
  • Assessed the impact of histone transfer on the epigenetic inheritance of silent chromatin domains.

Main Results:

  • The DNA replication machinery and associated histone chaperones mediate symmetrical transfer of parental histones to daughter DNA strands.
  • This process of histone transfer is essential for the epigenetic inheritance of silent chromatin domains.

Conclusions:

  • Symmetrical parental histone transfer by the replication machinery is a key mechanism for maintaining epigenetic memory.
  • Understanding this process is critical for comprehending how chromatin states are stably inherited.