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Updated: May 22, 2026
04:59
Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm
Published on: April 12, 2019
Approach to a patient with elevated serum alkaline phosphatase
Asma Siddique1, Kris V Kowdley
1Department of Gastroenterology, Center for Liver Disease, Digestive Disease Institute, Seattle, WA 98111, USA.
Clinics in Liver Disease
|May 1, 2012
Summary
Cholestasis, a liver condition, involves bile flow issues and is identified by specific enzyme levels. Diagnosis uses imaging and liver biopsy, with research focusing on genetics and immunity for new treatments.
Area of Science:
- Hepatology and Gastroenterology
- Biochemistry
- Immunology
Background:
- Cholestasis is characterized by impaired bile synthesis, secretion, or flow.
- It presents with elevated serum alkaline phosphatase and gamma-glutamyltransferase, disproportionate to aminotransferase levels.
Observation:
- Diagnostic workup involves visualizing the biliary tree via cholangiography.
- Liver histology evaluation is a key component in diagnosing cholestasis.
Findings:
- Current understanding highlights the role of genetic factors and immune mechanisms in cholestasis pathogenesis.
- Elevated alkaline phosphatase and gamma-glutamyltransferase are key biochemical markers.
Implications:
- Advances in understanding cholestasis pathogenesis may lead to novel therapeutic strategies.
- Future treatments could target genetic and immune pathways for improved patient outcomes.
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