Related Experiment Video
Updated: May 22, 2026

11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Rare or unusual forms of psoriasis]
1Clinique Dermatologique, Faculté de Médecine, Université de Strasbourg, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg cedex, France. Bernard.cribier@chru-strasbourg.fr
Annales De Dermatologie Et De Venereologie
|May 1, 2012
Summary
Psoriasis presents in rare forms beyond plaque-type, affecting mucous membranes, palms, soles, and nails. These unusual clinical presentations impact patient quality of life and require careful diagnosis.
Area of Science:
- Dermatology
- Clinical Medicine
Context:
- Psoriasis commonly manifests as plaque-type lesions.
- Rare clinical presentations of psoriasis include mucosal involvement, unusual distributions, and pustular forms.
Purpose:
- To highlight the diverse and rare clinical presentations of psoriasis.
- To emphasize the importance of recognizing less common psoriatic lesions.
Summary:
- Psoriasis exhibits varied presentations beyond typical plaques, affecting mucous membranes (genitals, tongue, lips, eyelids), palms, soles, and acral areas.
- Rare forms include psoriasis gyrata, Blaschko linear psoriasis, pustular psoriasis variants like Acrodermatitis Continua, and pachydermoperiostosis with characteristic radiographic findings.
- These presentations can cause pain, reduced quality of life, and involve significant nail pathology.
Impact:
- Enhances clinical awareness of uncommon psoriatic manifestations.
- Aids in timely diagnosis and management of rare psoriasis types.
- Improves understanding of the full spectrum of psoriasis pathology.
Related Concept Videos
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Unusual Results
Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value = μ + 2σ
Minimum unusual value...
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value = μ + 2σ
Minimum unusual value...
Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...