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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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T Cell Types and Functions

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Skin Cancer

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Related Experiment Video

Updated: May 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

[Pathogenesis of psoriasis].

D Jullien1

  • 1Université de Lyon, Lyon F-69003, France.

Annales De Dermatologie Et De Venereologie
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Psoriasis arises from complex interactions between genetic, immune, and skin cell factors, not a single cause. Understanding these combined abnormalities is key to unraveling the disease

Related Experiment Videos

Last Updated: May 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology and immunology, focusing on the complex pathophysiology of psoriasis.

Context:

  • Psoriasis is characterized by significant polymorphism, stemming from interactions between genetic susceptibility, immunological mechanisms, and environmental factors.
  • The exact origin of psoriasis is debated, with evidence suggesting it arises from a combination of immune system disorders and primary changes in skin cells (keratinocytes and stromal cells).

Purpose:

  • To provide a current overview of the physiopathology of psoriasis.
  • To explore the interplay between adaptive immunity (T-cells), innate immunity, and keratinocyte abnormalities in disease development.

Summary:

  • Psoriasis pathogenesis involves intricate interactions, where T-cells are crucial, but innate immunity and keratinocyte defects are increasingly recognized.
  • Numerous psoriasis susceptibility genes are linked to immune functions, while others point to primary keratinocyte abnormalities, highlighting a multifactorial etiology.
  • Recent research, including murine models, focuses on keratinocyte-targeted modifications, underscoring their role alongside immune system dysregulation.

Impact:

  • This review synthesizes current knowledge on psoriasis pathophysiology, aiding researchers and clinicians in understanding the disease's complex origins.
  • Highlights the need to consider combined abnormalities in both immune and epithelial compartments for a comprehensive understanding of psoriasis development.