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Updated: May 22, 2026

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
Published on: February 4, 2011
A novel approach to the uniform distribution of liquid in multi-channel (electrochemical) flow-through cells
Karel Lacina1, Jiří Vondál, Petr Skládal
1Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic. lacinak@chemi.muni.cz
Abstract:
Four-channel flow-through electrochemical cell working in thin-layer regime was designed, fabricated and characterized experimentally and in computational fluid dynamics (CFD) simulations. The new principle of operation allows reproducible splitting of a stream of liquid into multiple flow channels. Systems comprising of 2-, 3-, 4- and 8-channels were tested. The proper function of the cell is given by the ratio of the cross-sections of the fluidic element collecting chamber and the particular flow paths among which the liquid is distributed. Suitable flow rates providing uniform liquid distribution were evaluated and the results were compared to CFD modeling. The flow-through cells designed according to the proposed principle can be simply incorporated in automated routine analysis as only one inlet and one common outlet are required.

