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Updated: May 22, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

[Daptomycin in the context of antimicrobial resistance in Gram-positive bacteria]

Francisco Javier Candel González1

  • 1Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Madrid, España. fj.candel@terra.es

Enfermedades Infecciosas Y Microbiologia Clinica
|May 1, 2012
PubMed

Insights

Antimicrobial-resistant Gram-positive bacterial infections are common. Daptomycin offers an effective treatment alternative for severe infections, unlike bacteriostatic agents like linezolid and tigecycline.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Context:

  • Rising prevalence of antimicrobial-resistant Gram-positive bacteria (GPB) in healthcare settings.
  • Increasing microbiological cost associated with glycopeptide use, including resistance and tolerance.
  • Need for effective treatment strategies against challenging GPB infections.

Purpose:

  • To review current therapeutic options for Gram-positive bacterial infections.
  • To evaluate the efficacy and limitations of vancomycin, linezolid, tigecycline, and daptomycin.
  • To highlight daptomycin as a potent alternative for severe GPB infections.

Summary:

  • Glycopeptide use leads to resistance and tolerance issues in GPB.
  • Linezolid and tigecycline are bacteriostatic, limiting their use in severe infections.
  • Daptomycin exhibits potent early bactericidal activity and is effective against resistant strains.

Impact:

  • Provides insights into managing complex Gram-positive bacterial infections.
  • Informs clinical decision-making regarding antibiotic selection.
  • Suggests daptomycin as a valuable therapeutic option for severe and resistant infections.

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