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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies IV: Magnetic Resonance Imaging01:27

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Published on: October 20, 2017

Multimodality imaging in amyloidosis.

Stephanie Howard1, Jyothi Jagannathan, Katherine Krajewski

  • 1Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA. sahoward@partners.org

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Amyloidosis is a rare protein deposition disease that affects organs and often evades early diagnosis due to its varied presentation. This review helps radiologists identify amyloidosis using multimodality imaging, especially in patients with hematologic malignancies.

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Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Area of Science:

  • Radiology
  • Pathophysiology
  • Protein Deposition Diseases

Background:

  • Amyloidosis is a rare group of diseases characterized by protein deposition in organs.
  • Its nonspecific symptoms and variable course complicate early diagnosis.
  • Radiologists face challenges diagnosing amyloidosis, particularly when it co-occurs with hematologic malignancies.

Purpose of the Study:

  • To familiarize radiologists with amyloidosis pathophysiology and classifications.
  • To illustrate the diverse appearances of amyloidosis across different organs using multimodality imaging.
  • To enhance the recognition of amyloidosis in challenging clinical scenarios.

Main Methods:

  • Review of amyloidosis pathophysiology and classifications.
  • Multimodality imaging examples demonstrating amyloid deposition.
  • Discussion of diagnostic challenges in patients with concurrent hematologic malignancies.

Main Results:

  • Amyloidosis presents with variable clinical and imaging findings.
  • Multimodality imaging is crucial for visualizing amyloid deposition.
  • Concurrent amyloidosis in patients with hematologic malignancies poses diagnostic difficulties.

Conclusions:

  • Radiologists must consider amyloidosis in patients with unexplained findings, especially those with chronic illnesses or hematologic malignancies.
  • Familiarity with amyloidosis pathophysiology and imaging is key for timely diagnosis.
  • Multimodality imaging aids in detecting and characterizing amyloidosis throughout the body.