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Updated: May 22, 2026

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Evaluation of rate-dependency and internal clock effects of D-amphetamine
Vladimir Orduña1, Ana García, Arturo Bouzas
1Facultad de Psicología, Universidad Nacional Autónoma de México, México D.F., Mexico. vladord@unam.mx
Abstract:
The impact of two doses of d-amphetamine on rats' peak-interval performance was evaluated at two different points of training: with minimum training, 20 sessions, and with extended training, 120 sessions. At both points of training, none of the doses changed the location of the peak time; however, both doses caused a significant increase in the standard deviation of the response distribution during peak trials. Both results are incompatible with some previous empirical results, and with timing accounts that assume that dopamine modulates the pacemaker rate, but are compatible with a rate-dependent effect.
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