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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
REM Sleep Behavior Disorder01:15

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REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
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Updated: May 22, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

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Published on: January 9, 2015

Circadian rhythms in obsessive-compulsive disorder.

Klaus W Lange1, Katharina M Lange, Joachim Hauser

  • 1Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany. klaus.lange@psychologie.uni-regensburg.de

Journal of Neural Transmission (Vienna, Austria : 1996)
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) involves disrupted circadian rhythms. Agomelatine, an antidepressant, may help resynchronize these rhythms and improve treatment-refractory OCD outcomes.

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Area of Science:

  • Neurobiology
  • Psychiatry
  • Sleep Medicine

Background:

  • The underlying causes and brain mechanisms of obsessive-compulsive disorder (OCD) remain incompletely understood.
  • Altered circadian rhythms, hormonal imbalances, and delayed sleep phases are increasingly recognized as relevant factors in OCD.
  • Research is focusing on the connection between circadian dysregulation and OCD pathophysiology.

Purpose of the Study:

  • To review current findings on circadian abnormalities in patients with obsessive-compulsive disorder.
  • To explore the potential of interventions targeting circadian rhythms for OCD treatment.

Main Methods:

  • Literature review of studies investigating circadian rhythms in obsessive-compulsive disorder.
  • Analysis of research on hormonal dysregulation and sleep phase delays in OCD.
  • Examination of the effects of agomelatine and chronotherapy on OCD symptoms.

Main Results:

  • Evidence suggests significant circadian rhythm disturbances in individuals with OCD.
  • Agomelatine, a novel antidepressant, demonstrates potential in resynchronizing circadian rhythms.
  • Augmentative use of agomelatine and adjunctive chronotherapy may benefit patients with treatment-refractory OCD.

Conclusions:

  • Circadian abnormalities are a notable feature in obsessive-compulsive disorder.
  • Pharmacological and non-pharmacological interventions targeting circadian rhythms show promise for improving OCD treatment outcomes.
  • Further research into chronobiology may offer novel therapeutic strategies for OCD.