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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Specific surface modification of the acetylene-linked glycolipid vesicle by click chemistry
Hidehiro Ito1, Toshiaki Kamachi, Eiji Yashima
1Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-38, Nagatsuta, Yokohama 226-8501, Japan.
Chemical Communications (Cambridge, England)
|May 1, 2012
Abstract:
A novel glycolipid with a terminal acetylene was synthesized and used to prepare unilamellar vesicles. Using these vesicles, a convenient method was developed for the specific modification of the vesicle surface using the photoresponsive copper complex [Cu(OH(2))(cage)] as the catalyst for a click reaction.
