Rethinking the blastema
Related Experiment Video
Updated: May 22, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
Jeong S Hyun1, Michael T Chung, Victor W Wong
1Stanford, Calif. From the Hagey Laboratory for Pediatric Regenerative Medicine, the Division of Plastic and Reconstructive Surgery, Department of Surgery, and the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine.
Abstract:
The phenomenon of tissue regeneration has been well documented across many species. Although some possess the capacity to completely restore an entire amputated limb, others are limited to just the distal digit tip. Initiation of limb regeneration has been described to start with the formation of a blastema, the composition of which has long been thought to consist of undifferentiated pluripotent cells derived through the process of dedifferentiation. Competing theories have been proposed, however, including cellular contributions through transdifferentiation and tissue-specific stem cells. Recent studies have now begun to shed light on this controversy, demonstrating tissue resident stem cells to be an evolutionarily conserved measure for limb regeneration.
More Related Videos
Related Concept Videos
Cleavage and Blastulation
Zygotic Development And Stem Cell Formation
Whole Body Regeneration
Gastrulation
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Methods of Nuclear Reprogramming

