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Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Related Experiment Video

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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

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Published on: November 20, 2015

Calcified cerebral cryptococcal granuloma.

Jing-Qi Zhu1, Xiao-Feng Tao, Wei-Qun Bao

  • 1Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai, China.

Indian Journal of Pediatrics
|May 1, 2012
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Summary

This case study highlights a rare calcified cerebral cryptococcal granuloma in a 12-month-old infant presenting with seizures. Early diagnosis and treatment are crucial for managing this unusual intracranial mass.

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Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Neuroradiology

Background:

  • Cerebral cryptococcal granuloma is a rare fungal infection of the brain.
  • Calcification within these granulomas is exceptionally uncommon, particularly in infants.

Observation:

  • A 12-month-old girl presented with a 6-month history of seizures.
  • Imaging revealed an irregular calcified focus in the right parieto-occipital region, mimicking vascular malformations.
  • Histopathology confirmed cerebral cryptococcal granuloma.

Findings:

  • The infant's clinical presentation and imaging findings were atypical for cerebral cryptococcal granuloma.
  • Diagnosis was confirmed through histopathological examination.
  • Surgical resection followed by antifungal and anticonvulsant therapy yielded a positive outcome.

Implications:

  • Cerebral cryptococcal granuloma, though rare, should be considered in the differential diagnosis of intracranial calcified masses in infants.
  • This case underscores the importance of considering infectious etiologies in pediatric neurological disorders.
  • Early recognition and appropriate management are vital for improving patient outcomes.