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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Related Experiment Video

Updated: May 22, 2026

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes
07:41

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Engineering particles for therapeutic delivery: prospects and challenges.

Yan Yan1, Georgina K Such, Angus P R Johnston

  • 1fcaruso@unimelb.edu.au

ACS Nano
|May 2, 2012
PubMed
Summary

Advanced nanoengineered particles now target tumors, driving innovation in drug delivery. Future particle design will enhance specificity for improved targeted therapies by controlling properties and understanding biological barriers.

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

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Last Updated: May 22, 2026

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes
07:41

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Nanoengineered particles are increasingly used for drug formulation and passive tumor targeting, with recent clinical successes.
  • Innovations in particle engineering allow precise control over surface functionality, size, shape, and rigidity.
  • Advances in understanding disease-specific characteristics offer new avenues for targeted therapy development.

Purpose of the Study:

  • To review recent advancements in particle-based therapeutic delivery.
  • To discuss key concepts in particle design for next-generation therapeutics.
  • To highlight biological barriers impacting targeted therapy efficacy.

Main Methods:

  • Literature review of recent progress in nanoengineered particle development.
  • Analysis of enabling technologies and chemistries for particle property control.
  • Discussion of biological barriers relevant to targeted drug delivery.

Main Results:

  • Nanoengineered particles have achieved clinical relevance in drug formulation and tumor targeting.
  • Control over particle properties (surface, size, shape, rigidity) is advancing rapidly.
  • New opportunities exist for enhancing particle specificity by integrating disease-related characteristics.

Conclusions:

  • Continued innovation in particle design is crucial for next-generation targeted therapies.
  • Understanding and overcoming biological barriers is essential for effective particle delivery.
  • The field is poised for significant advancements in precision medicine through advanced particle engineering.