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Osteoblastic osteosarcoma in a rabbit
Megumi Ishikawa1, Hirotaka Kondo, Mamoru Onuma
1Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Comparative Medicine
|May 2, 2012
Summary
A rare osteosarcoma bone tumor was identified in a domestic rabbit
Area of Science:
- Veterinary Pathology
- Oncology
- Rabbit Medicine
Background:
- Osteosarcoma is a primary bone malignancy.
- Domestic rabbits (Oryctolagus cuniculus) can develop various tumors.
- Bone tumors in rabbits are uncommon but documented.
Observation:
- A domestic rabbit presented with an osteosarcoma in the tarsal joint and distal tibia.
- Histological examination revealed ovoid to short-spindle cells with giant cells producing osteoids.
- Micrometastases were detected in the rabbit's lungs.
Findings:
- The tumor cells expressed osteocalcin, confirming osteoblastic origin.
- This case represents a productive osteoblastic osteosarcoma.
- A review of 10 cases indicates osteosarcoma is the most common bone tumor in rabbits.
Implications:
- Osteoblastic osteosarcoma is the most frequent bone tumor in rabbits.
- Skull and facial bones are common sites for rabbit osteosarcomas.
- This case adds to the understanding of osteosarcoma in rabbits, aiding diagnosis and treatment.
