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Related Experiment Video

Updated: May 22, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate.

V M Smith¹, T Oliphant, M Shareef

¹Department of Dermatology, Leeds General Infirmary, Leeds, UK. vanessasmith@doctors.org.uk

Clinical and Experimental Dermatology

|May 3, 2012

Summary

This case study details calciphylaxis, a rare vascular condition, in a patient without kidney failure or hyperparathyroidism. The presentation was linked to trauma, compression, and a Factor V Leiden mutation, successfully treated with sodium thiosulfate.

Related Experiment Videos

Last Updated: May 22, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Area of Science:

Vascular Medicine
Dermatology
Nephrology

Background:

Calciphylaxis is a rare, severe condition involving arterial calcification and skin infarction.
It typically occurs in patients with end-stage renal disease or hyperparathyroidism.

Observation:

A 58-year-old man with asthma on long-term prednisolone and calcium supplementation presented with calciphylaxis.
He had no history of renal failure or abnormal parathyroid function.
The condition was potentially triggered by trauma and compression bandaging.

Findings:

The patient was heterozygous for the Factor V Leiden mutation.
This represents a unique case of calciphylaxis without common risk factors.
Intravenous sodium thiosulfate led to a prompt positive response.

Implications:

Highlights calciphylaxis as a possibility even without typical risk factors like renal failure.
Suggests potential roles for trauma, compression, and Factor V Leiden in disease precipitation.
Demonstrates the efficacy of sodium thiosulfate in atypical calciphylaxis cases.