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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Related Experiment Video

Updated: May 22, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Current issues in peripheral neuropathy.

Thomas H Brannagan1

  • 1Columbia University, College of Physicians and Surgeons, 710 W 168th Street, New York, NY 10032, USA. Tb2325@columbia.edu

Journal of the Peripheral Nervous System : JPNS
|May 3, 2012
PubMed
Summary

Peripheral neuropathy affects 20 million Americans, yet diagnosis and treatment are often delayed. Current treatments only manage symptoms or underlying causes, not nerve fiber dysfunction or regeneration.

Area of Science:

  • Neurology
  • Nerve Regeneration
  • Pain Management

Background:

  • Peripheral neuropathy impacts an estimated 20 million people in the U.S.
  • Many patients face diagnostic delays, lack awareness, or receive no treatment.
  • Existing treatments focus on underlying conditions or pain, not nerve repair.

Purpose of the Study:

  • Highlight the unmet need for treatments that address nerve fiber dysfunction and regeneration in peripheral neuropathy.
  • Emphasize the prevalence and challenges associated with idiopathic neuropathy.
  • Underscore the limitations of current therapeutic options for neuropathic pain.

Main Methods:

  • Literature review of current treatment modalities for peripheral neuropathy.
  • Analysis of diagnostic and treatment gaps.

Related Experiment Videos

Last Updated: May 22, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

  • Review of FDA-approved medications for specific neuropathies and neuropathic pain.

    • Main Results:

    • Current treatments for peripheral neuropathy do not address nerve fiber dysfunction or promote regeneration.
    • Idiopathic neuropathy is common, representing a significant portion of all neuropathy cases.
    • Many patients find existing pain medications for neuropathy ineffective or poorly tolerated.

    Conclusions:

    • There is a critical need for novel therapeutic strategies targeting nerve regeneration and neuropathic pain mechanisms.
    • Improved diagnostic methods and timely treatment initiation are essential for better patient outcomes.
    • Further research into neuropathy's underlying mechanisms is crucial to address this significant unmet medical need.