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Updated: Apr 3, 2026
08:33
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
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Synuclein Deposition in Idiopathic Small-Fiber Neuropathy: A Pilot Study.
Matthew W Schelke1, Kurenai Tanji1, Thomas H Brannagan1
1Columbia University, Vagelos College of Physicians and Surgeons, New York, New York, USA.
Muscle & Nerve
|April 2, 2026
Summary
Alpha-synuclein deposition does not appear to cause idiopathic small-fiber neuropathy (SFN). Further research is needed to identify the causes of SFN, a condition impacting quality of life.
Area of Science:
- Neurology
- Pathology
- Immunohistochemistry
Background:
- Small-fiber neuropathy (SFN) is a condition with many causes, but approximately half of cases remain idiopathic.
- Alpha-synuclein deposition in nerve terminals is observed in Parkinson disease, suggesting a potential role in SFN.
Purpose of the Study:
- To investigate if alpha-synuclein deposition underlies idiopathic SFN.
- To determine if alpha-synuclein is a common cause of SFN.
Main Methods:
- Skin biopsy specimens from 17 SFN patients were co-stained for alpha-synuclein and PGP 9.5.
- Immunofluorescence microscopy was used to analyze nerve terminal staining.
Main Results:
- All specimens showed positive staining for PGP 9.5-positive nerve terminals.
- No specimens demonstrated positive staining for alpha-synuclein.
Conclusions:
- Alpha-synuclein deposition is unlikely to be a common cause of idiopathic SFN.
- The underlying causes of idiopathic SFN remain unknown, necessitating further investigation into novel etiologies.
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