Related Experiment Video
Updated: Aug 19, 2026

Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment
Published on: June 5, 2015
The activated keratinocyte: up regulation of cell adhesion and migration during wound healing
1University of Texas Southwestern Medical Center, Dallas 75235.
Abstract:
Keratinocytes play different roles in normal and wounded skin. In normal skin, these cells are specialized for differentiation. In wounded skin, they are specialized for migration. This article discusses the idea that migratory-competent keratinocytes are "activated." Changes that characterize the activation process include increased cell attachment, spreading, focal adhesion formation, and migration. In part, these changes can be explained by enhanced expression of alpha 5 integrin subunits and reorganization of beta 1 integrin subunits.
Related Concept Videos
Cell Migration
Cell Migration
Intracellular Signaling Affects Focal Adhesions
Some...
Anchoring Junctions
Renewal of Skin Epidermal Stem Cells
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

