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DNA-binding small molecules as inhibitors of transcription factors

Chung-Hang Leung1, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma

  • 1Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China. duncanleung@umac.mo

Medicinal Research Reviews
|May 3, 2012
PubMed

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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