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[Changes in systemic circulation and organ blood flow during induced total spinal block]
M Kobori1, H Negishi, Y Masuda
1Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Masui. the Japanese Journal of Anesthesiology
|October 1, 1990
Summary
Total spinal block using lidocaine significantly reduced heart rate, mean arterial pressure, and cardiac index in dogs. Liver and brain blood flow decreased, while renal blood flow remained unchanged.
Area of Science:
- Anesthesiology
- Cardiovascular Physiology
- Surgical Research
Context:
- Lidocaine is a common local anesthetic.
- Total spinal block is a potential complication of regional anesthesia.
- Understanding its effects on circulation is crucial for patient safety.
Purpose:
- To investigate the hemodynamic and organ blood flow changes induced by total spinal block with lidocaine in dogs.
- To compare the effects of two different doses of lidocaine.
Summary:
- Total spinal block with lidocaine in dogs led to significant decreases in heart rate (HR), mean arterial pressure (MAP), and cardiac index (CI).
- Systemic vascular resistance (SVR) remained unchanged.
- Organ blood flow was reduced in the liver and central nervous system (cerebral cortex, medullary substance) but not in the renal cortex.
Impact:
- Provides critical data on the cardiovascular and organ perfusion consequences of lidocaine-induced total spinal block.
- Informs anesthetic management and risk assessment for procedures involving regional anesthesia.
- Highlights potential organ-specific vulnerabilities during profound sympathetic blockade.