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Updated: May 22, 2026
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Relationship between poststroke depression and ischemic lesion location
Monton Wongwandee1, Sookjaroen Tangwongchai, Kammant Phanthumchinda
1Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand. aaaaark@yahoo.com
Summary
Early poststroke depression is linked to left-sided ischemic stroke lesions, female gender, and lack of hypertension. These factors contribute to the higher incidence of depression in stroke patients.
Area of Science:
- Neurology
- Psychiatry
- Medical Imaging
Background:
- Depression is more prevalent in stroke patients than in other conditions with similar disability levels.
- The association between poststroke depression and the location of ischemic stroke lesions remains a subject of debate.
Purpose of the Study:
- To investigate the relationship between the location of ischemic stroke lesions and the early onset of poststroke depression.
Main Methods:
- A cross-sectional study involving patients diagnosed with their first acute ischemic stroke.
- Brain CT and MRI scans were utilized to confirm stroke diagnosis, classify stroke subtypes, and pinpoint lesion locations.
- The Hamilton Depression Rating Scale assessed early poststroke depression within two weeks of stroke onset.
Main Results:
- Eleven out of thirty-nine patients (28.2%) exhibited early poststroke depression.
- Statistically significant factors associated with early poststroke depression included left-sided stroke lesions, female gender, and the absence of hypertension.
Conclusions:
- Left-sided ischemic stroke lesions, being female, and not having hypertension are identified as contributing factors to early poststroke depression.
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