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Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...

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Resisting resistance: practical decision tools for choosing antimicrobials safely.

Norma S Hannigan1, Deanna R Tolman, Elaine L Larson

  • 1School of Nursing, Columbia University, New York, New York 10032, USA. nsh2106@columbia.edu

Journal of the American Academy of Nurse Practitioners
|May 4, 2012
PubMed
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Antimicrobial resistance is increasing due to overprescribing. Evidence-based tools and strategies can help nurse practitioners (NPs) make optimal antimicrobial choices at the point of care, improving prescribing practices.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Evidence-Based Medicine

Background:

  • Antimicrobial resistance (AMR) is a growing global health threat.
  • Inappropriate antimicrobial prescribing, particularly by nurse practitioners (NPs), contributes to AMR.
  • Lack of accessible clinical decision-making tools is a factor in suboptimal prescribing.

Purpose of the Study:

  • To present evidence-based decision-making strategies for appropriate antimicrobial prescribing.
  • To highlight available support tools for optimizing antimicrobial use.
  • To underscore the need for improved prescribing practices among NPs.

Main Methods:

  • Literature review of journal articles.
  • Synthesis of information from Internet websites.
  • Consultation of reference texts.

Main Results:

  • Emerging resistant microbial strains necessitate updated treatment approaches.
  • Overprescribing of antimicrobials fuels the development of resistance.
  • Practical, evidence-based tools can guide optimal antimicrobial selection.

Conclusions:

  • Evidence-based strategies and tools are crucial for combating antimicrobial resistance.
  • Point-of-care decision support can enhance antimicrobial prescribing by NPs.
  • Optimizing antimicrobial choices is essential for effective patient care and public health.