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Updated: May 22, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis to benzocaine: the importance of concomitant positive patch test results
A J González-Rodríguez1, E M Gutiérrez-Paredes, Á Revert Fernández
1Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, España. ajavigo@hotmail.com
Abstract:
Local anesthetics are widely used in clinical practice, and adverse effects are not uncommon. Delayed hypersensitivity reactions are among the most common effects, but immediate-type reactions may also occur. Patch testing should be considered in patients with hypersensitivity reactions. We present a case of allergic contact dermatitis to benzocaine that was detected incidentally by patch testing and highlight the importance of correctly interpreting patch test results when there are concomitant positive reactions.
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Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...

