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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Adrenergic Agonists: Mixed-Action Agents01:28

Adrenergic Agonists: Mixed-Action Agents

Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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Adrenergic Agonists: Chemistry and Structure-Activity Relationship

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Separation of the aromatic...
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Adrenergic Agonists: Therapeutic Uses

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Updated: May 22, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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Methylphenidate-induced erections in a prepubertal child.

B D Kelly1, D J Lundon, D McGuinness

  • 1Department of Urology, Galway University Hospital, Ireland. drbriankelly@hotmail.com

Journal of Pediatric Urology
|May 4, 2012
PubMed
Summary
This summary is machine-generated.

Methylphenidate, used for attention deficit hyperactivity disorder (ADHD), can rarely cause priapism (unwanted erections). This rare side effect requires awareness due to potential long-term complications in children.

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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Area of Science:

  • Pediatric Pharmacology
  • Neuroscience
  • Adverse Drug Reactions

Background:

  • Methylphenidate is a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD).
  • Stimulant medications like methylphenidate are widely prescribed for pediatric ADHD management.
  • Understanding the full spectrum of adverse effects is crucial for safe prescribing.

Observation:

  • A prepubertal child experienced priapism after initiating sustained-release methylphenidate.
  • The adverse event occurred following an adjusted dosing schedule.
  • Priapism, a prolonged erection, is a rare but serious condition.

Findings:

  • Priapism is identified as a rare adverse reaction to methylphenidate.
  • This case highlights a potential genitourinary side effect of methylphenidate therapy.
  • The link between methylphenidate and priapism warrants further clinical attention.

Implications:

  • Physicians should be vigilant for priapism in children treated with methylphenidate.
  • Parents and caregivers need education on recognizing this rare adverse event.
  • Early recognition and management of methylphenidate-induced priapism are essential to prevent long-term sequelae.